In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support cancer cell growth.

中文翻译：

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当癌细胞被给予Lemo [NH3] s时，它们会产生Lemo [NH3] ade。

在正常的生理学中，新陈代谢的最终产物从体内排出。在肿瘤中，这些代谢废物由于新陈代谢失调和血管功能不足而积聚。Spinelli等。（2017）表明，乳腺癌细胞通过将氨回收用于氨基酸合成来适应氨的积累，这可以支持癌细胞的生长。