Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.

中文翻译：

---

不浪费，不浪费：乳酸氧化助长了TCA循环。

先前的研究表明线粒体呼吸对于肿瘤发生至关重要。Hui等。（2017）和Faubert等。（2017）证明了传统上被视为厌氧和好氧糖酵解的废物的乳酸，是正常组织和肿瘤中线粒体TCA循环的主要碳源。