Manganese(I)‐Catalyzed C−H (2‐Indolyl)methylation: Expedient Access to Diheteroarylmethanes,Angewandte Chemie International Edition

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Manganese(I)‐Catalyzed C−H (2‐Indolyl)methylation: Expedient Access to Diheteroarylmethanes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-01-09 , DOI: 10.1002/anie.201710060
Qingquan Lu ₁ , Sara Cembellín ₁ , Steffen Greßies ₁ , Santanu Singha ₁ , Constantin G. Daniliuc ₁ , Frank Glorius ₁

Affiliation

An unprecedented Mn^I‐catalyzed (2‐indolyl)methylation of heteroarenes is reported. This method makes use of an aromatizing cascade strategy to install a (2‐indolyl)methyl group into target molecules, thereby leading to the expedient synthesis of previously challenging and important unsymmetrical diheteroarylmethanes, in particular bis(2‐indolyl)methanes. The proposed cascade process comprises the reorganization of multiple bonds with controlled regioselectivity and high atom economy and can be performed on a gram‐scale. Furthermore, a metal‐free C−H propargylation is observed. The diverse application of this method is also demonstrated.

中文翻译：

锰（I）催化的CH（2-吲哚基）甲基化：方便地获得二杂芳基甲烷

据报道，前所未有的Mn ^I催化杂芳烃的（2-吲哚基）甲基化。该方法利用芳构化级联策略将（2-吲哚基）甲基安装到目标分子中，从而方便地合成先前具有挑战性且重要的不对称二杂芳基甲烷，特别是双（2-吲哚基）甲烷。所提出的级联过程包括具有可控区域选择性和高原子经济性的多个键的重组，并且可以克级进行。此外，观察到无金属的CH炔丙基化。还演示了该方法的各种应用。

更新日期：2018-01-09

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