NRPS assembly line: The antibacterial peptide curacomycin was biosynthesized by nonribosomal peptide synthetases (NRPSs) and the unusual amino acid 5‐chlorotryptophan was synthesized by tryptophan halogenase. In order to find a new halogenated peptide, genome mining with focus on the halogenase gene existing near NRPS genes was performed. As a result, a new antibacterial peptide, named curacomycin, was isolated. As large genome data of bacteria are accumulated in public databases, the genome mining approach is a very powerful and efficient tool to find new bioactive compounds. More information can be found in the Full Paper by Shinya Kodani et al. on page 1838 in Issue 12, 2017 (DOI: 10.1002/ajoc.201700433).

中文翻译：

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封面内容：基于基因组采矿的新型抗菌肽库拉霉素的分离和结构测定（Asian J. Org。Chem。12/2017）

NRPS生产线：抗菌肽库拉霉素是通过非核糖体肽合成酶（NRPS）进行生物合成的，而异常氨基酸5-氯色氨酸是通过色氨酸卤化酶合成的。为了找到新的卤化肽，进行了集中在NRPS基因附近存在的卤化酶基因的基因组挖掘。结果，分离出了一种新的抗菌肽，命名为curacomycin。由于大量细菌基因组数据已在公共数据库中积累，因此基因组挖掘方法是一种非常强大有效的工具，可以找到新的生物活性化合物。可以在Shinya Kodani等人的《全文》中找到更多信息。就在第12期，2017年1838页（：10.1002 / ajoc.201700433 DOI）。