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Effects of Pressure and pH on the Hydrolysis of Cytosine: Implications for Nucleotide Stability around Deep‐Sea Black Smokers
ChemBioChem ( IF 3.2 ) Pub Date : 2018-02-06 , DOI: 10.1002/cbic.201700555
Christopher P. Lepper 1 , Martin A. K. Williams 2 , David Penny 1 , Patrick J. B. Edwards 1 , Geoffrey B. Jameson 2
Affiliation  

Back to the beginning: The relatively low chemical stability of cytosine compared with other nucleobases is a key concern in origin‐of‐life scenarios, but the effect of pressure on the rate of hydrolysis of cytosine to uracil has remained unknown. At high (200 MPa) pressures, the half‐life of cytosine at 100 °C is halved to 8.6 days compared with that at ambient pressure.
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中文翻译:

压力和pH对胞嘧啶水解的影响:对深海黑烟民周围核苷酸稳定性的影响

回到开始:与其他核碱基相比,胞嘧啶的化学稳定性相对较低,这是生命起源场景中的一个主要问题,但是压力对胞嘧啶水解为尿嘧啶的速率的影响仍然未知。在高压(200 MPa)下,胞嘧啶在100°C的半衰期比在环境压力下的半衰期缩短了8.6天。
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更新日期:2018-02-06
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