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A mannose-conjugated multi-layered polymeric nanocarrier system for controlled and targeted release on alveolar macrophages†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2017-12-04 00:00:00 , DOI: 10.1039/c7py02000g Rajendran Amarnath Praphakar 1, 2, 3, 4, 5 , Harshavardhan Shakila 4, 5, 6, 7, 8 , Vijayan N. Azger Dusthackeer 8, 9, 10, 11 , Murugan A. Munusamy 12, 13, 14, 15 , Suresh Kumar 16, 17, 18, 19 , Mariappan Rajan 1, 2, 3, 4, 5
Polymer Chemistry ( IF 4.1 ) Pub Date : 2017-12-04 00:00:00 , DOI: 10.1039/c7py02000g Rajendran Amarnath Praphakar 1, 2, 3, 4, 5 , Harshavardhan Shakila 4, 5, 6, 7, 8 , Vijayan N. Azger Dusthackeer 8, 9, 10, 11 , Murugan A. Munusamy 12, 13, 14, 15 , Suresh Kumar 16, 17, 18, 19 , Mariappan Rajan 1, 2, 3, 4, 5
Affiliation
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To improve the performance of drug delivery systems in macrophages, targeted ligand-conjugated polymeric carriers have been realized to be vital for targeted, sustainable and controlled drug release with remarkable biocompatibility and bioavailability. The primary goal of the present study was to fabricate a multi-layered polymeric nanocarrier system with a targeting moiety for the release of multiple drugs (rifampicin and isoniazid) for pulmonary tuberculosis. In this regard, sodium alginate-grafted allylamine-rifampicin and chitosan-grafted allylamine-mannose were obtained as nano-sized materials by a simple and facile method. A series of physiochemical characterizations via FTIR, XRD, SEM, TEM, and AFM were performed to characterize and confirm the structure and shape of the nanocarriers. Via in vitro drug release studies, the patterns of release of rifampicin and isoniazid in response to a lysozyme environment were observed. Biological evaluations of the prepared nanopolymeric systems have been investigated by cell cytotoxicity, cellular uptake, and intracellular protein leakage and confirmed that future clinical applications of these materials in the field of tuberculosis are feasible.
中文翻译：
甘露糖缀合的多层聚合物纳米载体系统，用于在肺泡巨噬细胞上控制和靶向释放†
为了改善巨噬细胞中药物递送系统的性能，已经意识到靶向配体-缀合的聚合物载体对于靶向，可持续和可控药物释放具有显着的生物相容性和生物利用度至关重要。本研究的主要目标是制造具有靶向部分的多层聚合物纳米载体系统，以释放肺结核的多种药物（利福平和异烟肼）。在这方面，通过简单且容易的方法获得了藻酸钠接枝的烯丙胺-利福平和壳聚糖接枝的烯丙胺-甘露糖作为纳米级材料。通过FTIR，XRD，SEM，TEM和AFM进行了一系列的理化表征，以表征和确认纳米载体的结构和形状。通过体外药物释放研究，观察到了响应溶菌酶环境的利福平和异烟肼的释放模式。已通过细胞的细胞毒性，细胞摄取和细胞内蛋白质泄漏研究了制备的纳米聚合物系统的生物学评估，并证实了这些材料在结核病领域的未来临床应用是可行的。
更新日期：2017-12-04
中文翻译：
甘露糖缀合的多层聚合物纳米载体系统，用于在肺泡巨噬细胞上控制和靶向释放†
为了改善巨噬细胞中药物递送系统的性能，已经意识到靶向配体-缀合的聚合物载体对于靶向，可持续和可控药物释放具有显着的生物相容性和生物利用度至关重要。本研究的主要目标是制造具有靶向部分的多层聚合物纳米载体系统，以释放肺结核的多种药物（利福平和异烟肼）。在这方面，通过简单且容易的方法获得了藻酸钠接枝的烯丙胺-利福平和壳聚糖接枝的烯丙胺-甘露糖作为纳米级材料。通过FTIR，XRD，SEM，TEM和AFM进行了一系列的理化表征，以表征和确认纳米载体的结构和形状。通过体外药物释放研究，观察到了响应溶菌酶环境的利福平和异烟肼的释放模式。已通过细胞的细胞毒性，细胞摄取和细胞内蛋白质泄漏研究了制备的纳米聚合物系统的生物学评估，并证实了这些材料在结核病领域的未来临床应用是可行的。
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