Multiple frontal cortical brain regions have emerged as being important in pain processing, whether it be integrative, sensory, cognitive, or emotional. One such region, Brodmann Area 10 (BA 10), is the largest frontal brain region that has been shown to be involved in a wide variety of functions including risk and decision making, odor evaluation, reward and conflict, pain, and working memory. BA 10, also known as the anterior prefrontal cortex, frontopolar prefrontal cortex or rostral prefrontal cortex, is comprised of at least two cytoarchitectonic sub-regions, medial and lateral. To date, the explicit role of BA 10 in the processing of pain hasn’t been fully elucidated. In this paper, we first review the anatomical pathways and functional connectivity of BA 10. Numerous functional imaging studies of experimental or clinical pain have also reported brain activations and/or deactivations in BA 10 in response to painful events. The evidence suggests that BA 10 may play a critical role in the collation, integration and high-level processing of nociception and pain, but also reveals possible functional distinctions between the subregions of BA 10 in this process.

无论是整合的，感觉的，认知的还是情感的，多个额叶皮质脑区域已经在疼痛处理中变得很重要。Brodmann Area 10（BA 10）是其中一个这样的区域，它是最大的额叶大脑区域，已被证明参与多种功能，包括风险和决策，气味评估，奖励与冲突，痛苦和工作记忆。BA 10，也称为前额叶前皮层，额极前额叶皮层或眼前额叶皮层，由内侧和外侧的至少两个细胞结构子区域组成。迄今为止，尚未完全阐明BA 10在疼痛处理中的明确作用。在本文中，我们首先回顾了BA 10的解剖学途径和功能连接性。对实验性或临床性疼痛的众多功能成像研究也报告了BA 10中响应疼痛事件的大脑激活和/或失活。有证据表明，BA 10可能在伤害感受和疼痛的整理，整合和高级处理中发挥关键作用，但也揭示了BA 10在此过程中各个子区域之间可能存在的功能区别。