In eukaryotes, a cytosolic ribosome quality control complex recycles erroneously stalled ribosomes and modifies faulty nascent chains by ubiquitination and by C-terminal Ala- and Thr-extension (CAT-tailing). Reported recently in Cell, Izawa et al. identify cytosolic Vms1 (VCP/Cdc48-associated mitochondrial stress-responsive 1) as an inhibitor of CAT-tailing, which prevents mitochondrial dysfunction caused by imported CAT-tailed polypeptides.

中文翻译：

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Vms1：保护线粒体的胞质CAT尾巴拮抗剂。

在真核生物中，胞质核糖体质量控制复合物会错误地回收停滞的核糖体，并通过泛素化和C末端Ala和Thr延伸（CAT尾部）修饰有缺陷的新生链。Izawa等人最近在Cell中进行了报道。确定胞质Vms1（与VCP / Cdc48相关的线粒体应激反应1）是CAT尾巴的抑制剂，可防止CAT尾巴多肽引起的线粒体功能障碍。