A cohort-friendly biomonitoring protocol has been developed for measuring biomarkers of exposure to disinfection by-products (trihalomethanes, THM) in urine using small initial volume (3 mL) and short analysis time (∼10 min) that facilitates the throughput of a large number of samples. The objective of this study was to optimise a cohort-friendly biomonitoring protocol for the determination of four THM analytes in human urine using gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ-MS/MS). The proposed methodology will facilitate the inclusion of such urinary THM measurements into large population health studies.

中文翻译：

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气相色谱—三重四极杆质谱法灵敏，快速地测定尿液中三卤甲烷的同类研究友好协议

已经开发了一种队列友好的生物监测方案，用于以较小的初始体积（3 mL）和较短的分析时间（〜10分钟）来测量尿液中消毒副产物（三卤甲烷，THM）暴露的生物标志物，从而有助于大批量的通量样本数。这项研究的目的是使用气相色谱与三重四极杆质谱（GC-QqQ-MS / MS）优化用于队列研究的生物监测方案，用于测定人尿中的四种THM分析物。拟议的方法将有助于将此类尿液THM测量值纳入大型人群健康研究。