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Protein Folding in the Presence of Water‐Soluble Cyclic Diselenides with Novel Oxidoreductase and Isomerase Activities
ChemBioChem ( IF 3.2 ) Pub Date : 2017-12-29 , DOI: 10.1002/cbic.201700624
Kenta Arai 1 , Haruhito Ueno 1 , Yuki Asano 1 , Gaurango Chakrabarty 2 , Shingo Shimodaira 1 , Govindasamy Mugesh 2 , Michio Iwaoka 1
Affiliation  

Foldase mimics: Water‐soluble cyclic diselenides mimic the multifunctional activity of protein disulfide isomerase (PDI) and its family enzymes by facilitating oxidative folding, disulfide formation/reduction, and repair of the scrambled disulfide bonds in misfolded proteins.
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中文翻译:

具有新型氧化还原酶和异构酶活性的水溶性环状二硒化物存在下的蛋白质折叠

折叠酶模拟物:水溶性环状二硒化物通过促进氧化折叠,二硫键的形成/还原以及错误折叠的蛋白质中混乱的二硫键的修复,来模拟蛋白质二硫键异构酶(PDI)及其家族酶的多功能活性。
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更新日期:2017-12-29
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