Whole‐Cell Cascade Biotransformations for One‐Pot Multistep Organic Synthesis,ChemCatChem

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Whole‐Cell Cascade Biotransformations for One‐Pot Multistep Organic Synthesis
ChemCatChem ( IF 3.8 ) Pub Date : 2018-02-23 , DOI: 10.1002/cctc.201701669
Shuke Wu ₁ , Zhi Li ₁

Affiliation

Performing one‐pot multi‐catalysis reactions is a revolutionary tool for multistep synthesis, representing a fast‐developing theme in catalysis field. To develop cascade reactions, enzymes are ideal catalysts due to their compatible reaction conditions. The implementation of enzyme cascades in recombinant microbial cells provides easily available self‐replicating catalysts for facile one‐pot biotransformations to produce a wide range of high‐value (chiral) chemicals. In this minireview, we summarize the recent development of whole‐cell cascade biotransformations according to the types of substrates, ranging from petrochemicals to biochemicals. Furthermore, we provide general instructions for the establishment of in vivo enzyme cascades, discuss the encountered problems and the corresponding solutions, and highlight the promising directions for future advance.

中文翻译：

一锅多步有机合成的全细胞级联生物转化

进行单锅多催化反应是多步合成的革命性工具，代表了催化领域一个快速发展的主题。为了发展级联反应，由于酶具有相容的反应条件，因此它们是理想的催化剂。重组微生物细胞中酶级联反应的实施为容易进行的一锅式生物转化提供了易于获得的自复制催化剂，以产生多种高价值（手性）化学品。在此小型审查中，我们根据基质的类型（从石油化学到生物化学）总结了全细胞级联生物转化的最新进展。此外，我们提供了建立体内酶级联反应的一般说明，讨论了遇到的问题和相应的解决方案，

更新日期：2018-02-23

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