Asymmetric Aldol Additions: A Guided-Inquiry Laboratory Activity on Catalysis,Journal of Chemical Education

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Asymmetric Aldol Additions: A Guided-Inquiry Laboratory Activity on Catalysis
Journal of Chemical Education ( IF 2.5 ) Pub Date : 2017-12-01 00:00:00 , DOI: 10.1021/acs.jchemed.7b00147
Jorge H. Torres King ₁ , Hong Wang ₂ , Ellen J. Yezierski

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Despite the importance of asymmetric catalysis in both the pharmaceutical and commodity chemicals industries, asymmetric catalysis is under-represented in undergraduate chemistry laboratory curricula. A novel guided-inquiry experiment based on the asymmetric aldol addition was developed. Students conduct lab work to compare the effectiveness of different catalysts in catalyzing the asymmetric aldol addition of a ketone and an aldehyde. Working in pairs, students use a variety of analytical techniques including 1-D and 2-D NMR spectroscopy and chiral chromatography and write their final report in the format of an ACS style publication. Although this experiment was designed for an advanced undergraduate synthesis laboratory course, it can be readily adapted for use in an organic or an inorganic laboratory course.

中文翻译：

不对称醛醇加成：催化的实验室指导活动

尽管不对称催化在制药和日用化工行业中都非常重要，但不对称催化在本科化学实验室课程中的代表性仍不足。提出了一种基于不对称羟醛加成的新型导引实验。学生们进行实验室工作，以比较不同催化剂在催化酮和醛的不对称醛醇加成反应中的有效性。学生们成对工作，使用各种分析技术，包括一维和二维核磁共振波谱法和手性色谱法，并以ACS风格的出版物格式撰写最终报告。尽管此实验是为高级本科生综合实验室课程设计的，但可以轻松地用于有机或无机实验室课程。

更新日期：2017-12-01

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