Hypolipidemic effect and protection ability of liver-kidney functions of melanin from Lachnum YM226 in high-fat diet fed mice,Food & Function

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Hypolipidemic effect and protection ability of liver-kidney functions of melanin from Lachnum YM226 in high-fat diet fed mice
Food & Function ( IF 5.1 ) Pub Date : 2017-12-01 00:00:00 , DOI: 10.1039/c7fo01294b
Fang Shi _{1,

2,

3,

4} , Jinglei Li _{1,

2,

3,

4} , Liuqing Yang _{1,

2,

3,

4} , Guohua Hou _{1,

2,

3,

4} , Ming Ye _{1,

2,

3,

4}

Affiliation

In the present study, we investigated the hypolipidemic properties of melanin from Lachnum YM226 (LM) in high-fat diet induced hyperlipidemic mice. After the hyperlipidemic model was established, mice were randomly divided into six groups, as follows: normal control group (NC), hyperlipidemic control group (HC), positive control group (7 mg kg⁻¹ d⁻¹ simvastatin) (PC) and LM groups (50, 100 and 200 mg kg⁻¹ d⁻¹ denoted as LM-50, LM-100 and LM-200, respectively). Subsequently, the body weight, organ indices, lipid metabolism, antioxidant properties and liver-kidney functions of the mice were examined. Moreover, the activities of lipoprotein metabolism enzymes in serum and liver tissue were examined to study the feasible mechanism. The results imply that LM could effectively reduce body weight, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and atherogenic index (AI), and increase high density lipoprotein cholesterol (HDL-C). Moreover, treatment with LM also increased the antioxidant enzymes activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) and reduced malondialdehyde (MDA) content relative to the HC group. In addition, the liver and kidney damage indices such as alanine aminotransferase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), creatinine (CRE), blood urea nitrogen (BUN) and uric acid were lowered. LM administration also significantly corrected disturbances of liver-kidney functions with no fatty deposits in the liver, resulting in a protective effect against renal histological alteration. The hypolipidemic effect occurred partly due to the regulation of hepatic lipase (HL) and lipoprotein lipase (LPL) in serum and liver to markedly decrease TG. This confirms the important role of LM in the prevention of hyperlipidemia.

中文翻译：

Lachnum YM226 黑色素对高脂饮食喂养小鼠的降血脂作用和肝肾功能的保护能力

在本研究中，我们调查了高脂饮食诱导的高脂血症小鼠的Lachnum YM226（LM）黑色素的降血脂特性。建立高脂血症模型后，将小鼠随机分为六组：正常对照组（NC），高脂血症对照组（HC），阳性对照组（7 mg kg ^-1 d ^-1 simvastatin）（PC）和LM组（50、100和200 mg kg ^-1 d ^-1分别表示为LM-50，LM-100和LM-200）。随后，检查了小鼠的体重，器官指数，脂质代谢，抗氧化特性和肝肾功能。此外，还对血清和肝组织中脂蛋白代谢酶的活性进行了研究，以研究可行的机制。结果表明，LM可以有效减轻体重，降低总胆固醇（TC），甘油三酸酯（TG），低密度脂蛋白胆固醇（LDL-C）和致动脉粥样硬化指数（AI），并增加高密度脂蛋白胆固醇（HDL-C）。此外，相对于HC组，用LM处理还可以增加超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-PX）的抗氧化酶活性，并降低丙二醛（MDA）含量。此外，降低了肝脏和肾脏的损害指数，如丙氨酸转氨酶（ALT），天冬氨酸转氨酶（AST），碱性磷酸酶（ALP），肌酐（CRE），血尿素氮（BUN）和尿酸。LM给药还可以显着纠正肝脏-肾脏功能的紊乱，而肝脏中没有脂肪沉积，从而对肾脏组织学改变具有保护作用。降血脂作用的出现部分是由于血清和肝脏中肝脂肪酶（HL）和脂蛋白脂肪酶（LPL）的调节显着降低了TG。这证实了LM在预防高脂血症中的重要作用。LM给药还可以显着纠正肝脏-肾脏功能的紊乱，而肝脏中没有脂肪沉积，从而对肾脏组织学改变具有保护作用。降血脂作用的出现部分是由于血清和肝脏中肝脂肪酶（HL）和脂蛋白脂肪酶（LPL）的调节显着降低了TG。这证实了LM在预防高脂血症中的重要作用。LM给药还可以显着纠正肝脏-肾脏功能的紊乱，而肝脏中没有脂肪沉积，从而对肾脏组织学改变具有保护作用。降血脂作用的出现部分是由于血清和肝脏中肝脂肪酶（HL）和脂蛋白脂肪酶（LPL）的调节显着降低了TG。这证实了LM在预防高脂血症中的重要作用。

更新日期：2017-12-01

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