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Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-12-01 00:00:00 , DOI: 10.1039/c7tb02763j Roger Honorato Piva 1, 2, 3, 4, 5 , Marina Campos Rocha 4, 5, 6, 7, 8 , Diógenes Honorato Piva 4, 5, 8, 9 , Oscar Rubem Klegues Montedo 5, 10, 11, 12, 13 , Hidetake Imasato 1, 2, 3, 4, 5 , Iran Malavazi 4, 5, 6, 7, 8 , Ubirajara Pereira Rodrigues-Filho 1, 2, 3, 4, 5
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-12-01 00:00:00 , DOI: 10.1039/c7tb02763j Roger Honorato Piva 1, 2, 3, 4, 5 , Marina Campos Rocha 4, 5, 6, 7, 8 , Diógenes Honorato Piva 4, 5, 8, 9 , Oscar Rubem Klegues Montedo 5, 10, 11, 12, 13 , Hidetake Imasato 1, 2, 3, 4, 5 , Iran Malavazi 4, 5, 6, 7, 8 , Ubirajara Pereira Rodrigues-Filho 1, 2, 3, 4, 5
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The transfer of pathogens from contaminated surfaces to patients is one of the main causes of health care-associated infections (HCAIs). Cases of HCAIs due to multidrug-resistant organisms have been growing worldwide, whereas inorganic nano-antimicrobials are valuable today for the prevention and control of HCAIs. Here, we present a cesium salt of phosphotungstic heteropolyacid (Cs2.5H0.5PW12O40) as a promising nanomaterial for use in antimicrobial product technologies. This water-insoluble Keggin salt exhibits a broad biocide spectrum against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi even under dark conditions. The Cs2.5H0.5PW12O40 nanoparticles (NPs) act as a proton-regulated antimicrobial whose activity is mediated on the release of hydronium ions (H3O+), yielding an in situ acidic pH several units below those tolerable by most of the fungal and bacterial nosocomial pathogens.
中文翻译：
用Cs 2.5 H 0.5 PW 12 O 40纳米颗粒与病原体抗衡：一种新型的质子调节抗菌剂†
病原体从受污染表面向患者的转移是卫生保健相关感染（HCAI）的主要原因之一。在世界范围内，由于具有多重耐药性的生物导致的HCAI病例不断增加，而如今，无机纳米抗菌剂对于HCAI的预防和控制具有重要意义。在这里，我们介绍了磷钨杂多酸铯盐（Cs 2.5 H 0.5 PW 12 O 40），它是用于抗菌产品技术的有前途的纳米材料。这种水不溶性的Keggin盐即使在黑暗条件下，对革兰氏阳性和革兰氏阴性细菌，酵母菌和丝状真菌也显示出广泛的杀生物剂谱。Cs 2.5 H 0.5 PW 12O 40纳米颗粒（NPs）作为质子调节的抗微生物剂，其活性是通过释放水合氢离子（H 3 O +）来介导的，其原位酸性pH值比大多数真菌和细菌性医院病原体可耐受的pH值低几个单位。
更新日期：2017-12-01
中文翻译：
用Cs 2.5 H 0.5 PW 12 O 40纳米颗粒与病原体抗衡：一种新型的质子调节抗菌剂†
病原体从受污染表面向患者的转移是卫生保健相关感染（HCAI）的主要原因之一。在世界范围内，由于具有多重耐药性的生物导致的HCAI病例不断增加，而如今，无机纳米抗菌剂对于HCAI的预防和控制具有重要意义。在这里，我们介绍了磷钨杂多酸铯盐（Cs 2.5 H 0.5 PW 12 O 40），它是用于抗菌产品技术的有前途的纳米材料。这种水不溶性的Keggin盐即使在黑暗条件下，对革兰氏阳性和革兰氏阴性细菌，酵母菌和丝状真菌也显示出广泛的杀生物剂谱。Cs 2.5 H 0.5 PW 12O 40纳米颗粒（NPs）作为质子调节的抗微生物剂，其活性是通过释放水合氢离子（H 3 O +）来介导的，其原位酸性pH值比大多数真菌和细菌性医院病原体可耐受的pH值低几个单位。
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