Advances in the synthesis of nitroxide radicals for use in biomolecule spin labelling,Chemical Society Reviews

当前位置： X-MOL 学术 › Chem. Soc. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Advances in the synthesis of nitroxide radicals for use in biomolecule spin labelling
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-12-01 00:00:00 , DOI: 10.1039/c6cs00550k
Marius M. Haugland _{1,

2,

3,

4,

5} , Janet E. Lovett _{5,

6,

7,

8,

9} , Edward A. Anderson _{1,

2,

3,

4,

5}

Affiliation

EPR spectroscopy is an increasingly useful analytical tool to probe biomolecule structure, dynamic behaviour, and interactions. Nitroxide radicals are the most commonly used radical probe in EPR experiments, and many methods have been developed for their synthesis, as well as incorporation into biomolecules using site-directed spin labelling. In this Tutorial Review, we discuss the most practical methods for the synthesis of nitroxides, focusing on the tunability of their structures, the manipulation of their sidechains into spin labelling handles, and their installation into biomolecules.

中文翻译：

用于生物分子自旋标记的一氧化氮自由基合成研究进展

EPR光谱学是一种越来越有用的分析工具，可用于探测生物分子的结构，动态行为和相互作用。氮氧化物自由基是EPR实验中最常用的自由基探针，并且已经开发出许多方法来合成它们，以及使用定点自旋标记将其掺入生物分子中。在本教程审查中，我们讨论了合成一氧化氮的最实用方法，重点是其结构的可调性，将其侧链操纵到旋转标记手柄中以及将其安装到生物分子中的方法。

更新日期：2017-12-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11