Development of sensitive detectors of Aβ aggregates and effective inhibitors of Aβ aggregation are of diagnostic importance and therapeutic implications for Alzheimer's disease (AD) treatment. Herein, a novel strategy has been presented by self-assembly of peptide conjugated Au nanorods (AuP) as multifunctional Aβ fibrillization detectors and inhibitors. Our design combines the unique high NIR absorption property of AuNRs with two known Aβ inhibitors, Aβ15-20 and polyoxometalates (POMs). The synthesized AuP can effectively inhibit Aβ aggregation and dissociate amyloid deposits with NIR irradiation both in buffer and in mice cerebrospinal fluid (CSF), and protect cells from Aβ-related toxicity upon NIR irradiation. In addition, with the shape and size-dependent optical properties, the nanorods can also act as effective diagnostic probes to sensitively detect the Aβ aggregates. This is the first report to integrate 3 segments, an Aβ-targeting element, a reporter and inhibitors, in one drug delivery system for AD treatment.

中文翻译：

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使用多功能肽共轭金纳米棒监测β-淀粉样蛋白聚集和化学光热治疗阿尔茨海默氏病

研发灵敏的Aβ聚集体检测剂和有效的Aβ聚集抑制剂对阿尔茨海默病（AD）的治疗具有重要的诊断意义和治疗意义。在本文中，通过自组装肽缀合的金纳米棒（AuP）作为多功能Aβ原纤化检测剂和抑制剂，提出了一种新的策略。我们的设计将AuNRs独特的高NIR吸收性能与两种已知的Aβ抑制剂Aβ15-20和多金属氧酸盐（POM）结合在一起。合成的AuP可以有效抑制Aβ聚集，并在缓冲液和小鼠脑脊髓液（CSF）中通过NIR辐照解离淀粉样蛋白沉积物，并保护细胞免受NIR辐照引起的Aβ相关毒性。此外，凭借形状和尺寸相关的光学特性，纳米棒还可以充当有效的诊断探针，以灵敏地检测Aβ聚集体。这是第一份在一个用于AD治疗的药物递送系统中整合3个片段（Aβ靶向元件，报道分子和抑制剂）的报告。