Ambient Ionization and Miniature Mass Spectrometry Systems for Disease Diagnosis and Therapeutic Monitoring,Theranostics

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Ambient Ionization and Miniature Mass Spectrometry Systems for Disease Diagnosis and Therapeutic Monitoring
Theranostics ( IF 12.4 ) Pub Date : 2017-07-20 , DOI: 10.7150/thno.19410
Wenpeng Zhang _{1,

2} , Xiao Wang _{1,

2} , Yu Xia _{3,

4} , Zheng Ouyang _{1,

2}

Affiliation

Mass spectrometry has become a powerful tool in the field of biomedicine. The combination of ambient ionization and miniature mass spectrometry systems could most likely fulfill a significant need in medical diagnostics, providing highly specific molecular information in real time for clinical and even point-of-care analysis. In this review, we discuss the recent development of ambient ionization and miniature mass spectrometers as well as their potential in disease diagnosis and therapeutic monitoring, with an emphasis on their capability in analysis of biofluids and tissues. We also speculate the future development of the integrated, miniature MS systems and provide our perspectives on the challenges in technical development as well as possible solutions for path forward.

中文翻译：

用于疾病诊断和治疗监测的环境电离和微型质谱系统

质谱分析已成为生物医学领域的有力工具。环境电离和微型质谱系统的结合很可能满足医疗诊断的重大需求，为临床甚至现场护理分析实时提供高度特异性的分子信息。在这篇综述中，我们讨论了环境电离和微型质谱仪的最新发展以及它们在疾病诊断和治疗监测方面的潜力，重点是它们在生物体液和组织分析方面的能力。我们还推测了集成微型 MS 系统的未来发展，并就技术开发中的挑战以及未来可能的解决方案提供了我们的观点。

更新日期：2017-12-01

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