Circular RNAs (circRNAs) are newly discovered endogenous non-coding RNAs featuring structural stability, high abundance, and tissue-specific expression. CircRNAs are prevalent and conserved in mammalian cells. They are involved in cellular processes and regulate gene expression at the transcriptional or post-transcriptional level by interacting with microRNAs (miRNAs) and other molecules. Recent studies have shown that circRNAs play an important role in the progression of various human diseases including atherosclerosis, nervous system disorders, diabetes, and cancer. In this review, we summarize the advances on endogenous circRNAs in eukaryotic cells and elucidate their diagnostic and prognostic significance in human cancers. Especially, we highlight the involvement of circRNAs in signal transduction pathways as well as their clinical potential to serve as biomarkers.

中文翻译：

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环状RNA：癌症相关信号通路的调节剂和人类癌症的潜在诊断生物标志物

环状RNA（circRNA）是新发现的内源性非编码RNA，具有结构稳定性，高丰度和组织特异性表达的特点。CircRNA在哺乳动物细胞中普遍存在并保持保守。它们参与细胞过程，并通过与microRNA（miRNA）和其他分子的相互作用在转录或转录后水平调节基因表达。最近的研究表明，circRNA在多种人类疾病的进展中起着重要作用，包括动脉粥样硬化，神经系统疾病，糖尿病和癌症。在这篇综述中，我们总结了真核细胞中内源性circRNA的研究进展，并阐明了它们在人类癌症中的诊断和预后意义。尤其，