Health systems underpin disease elimination and eradication programmes. In an elimination and eradication context, innovative research approaches are needed across health systems to assess readiness for programme reorientation, mitigate any decreases in effectiveness of interventions (‘effectiveness decay’), and respond to dynamic and changing needs. The malaria eradication research agenda (malERA) Refresh consultative process for the Panel on Health Systems and Policy Research identifies opportunities to build health systems evidence and the tools needed to eliminate malaria from different zones, countries, and regions and to eradicate it globally. The research questions are organised as a portfolio that global health practitioners, researchers, and funders can identify with and support. This supports the promotion of an actionable and more cohesive approach to building the evidence base for scaled-up implementation of findings. Gaps and opportunities discussed in the paper include delivery strategies to meet the changing dynamics of needs of individuals, environments, and malaria programme successes; mechanisms and approaches to best support accelerated policy and financial responsiveness at national and global level to ensure timely response to evidence and needs, including in crisis situations; and systems’ readiness tools and decision-support systems.

卫生系统是消除和根除疾病计划的基础。在消除和根除背景下，整个卫生系统需要创新的研究方法来评估规划重新定位的准备情况，减轻干预措施有效性的下降（“有效性衰减”），并应对动态和不断变化的需求。卫生系统和政策研究小组的疟疾根除研究议程（malERA）更新协商进程确定了建立卫生系统证据和消除不同地区、国家和地区疟疾以及在全球根除疟疾所需工具的机会。研究问题被组织为全球卫生从业者、研究人员和资助者可以识别和支持的组合。这支持推广一种可行且更具凝聚力的方法来建立证据基础，以扩大研究结果的实施。本文讨论的差距和机遇包括满足个人、环境和疟疾项目成功不断变化的需求的交付策略；最好地支持国家和全球层面加速政策和财政响应的机制和方法，以确保及时响应证据和需求，包括在危机情况下；以及系统的准备工具和决策支持系统。