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Repaglinide versus insulin for newly diagnosed diabetes in patients with cystic fibrosis: a multicentre, open-label, randomised trial.
The Lancet ( IF 168.9 ) Pub Date : 2018-02-01 , DOI: 10.1016/s2213-8587(17)30400-x
Manfred Ballmann , Dominique Hubert , Baroukh M Assael , Doris Staab , Alexandra Hebestreit , Lutz Naehrlich , Tanja Nickolay , Nicole Prinz , Reinhard W Holl , Ute Staden , Martin Claßen , Antje Schuster , Uwe Mellies , Hans-Georg Posselt , Matthias Wiebel , Ernst Rietschel , Martin Stern , Helmut Teschler , Christina Smaczny , Thomas Köhnlein , Vera Wienhausen-Wilke , Andreas Claaß , Thomas Biedermann , Gerd Dockter , Holger Köster , Helge Hebestreit , Ernst-Hinrich Ballke , Hans-Eberhard Heuer , Wolfgang Kamin , Peter Küster , Rüdiger Szczepanski , Klaus-Michael Keller , Horst Generlich , Hans-Georg Bresser , Matthias Kopp , Egbert Herting , Hans-Joachim Feickert , Jürgen Hautz , Birgit Schilling , Egbert Meyer , Marcus A Mall , Wolfram Wiebicke , Friedrich-Karl Tegtmeyer , Marguerite Honer , Helen Mosnier-Pudar , Gérard Lenoir , Jean-Jacques Robert , Laurence Kessler , Laurence Weiss , Raphaële Nove-Josserand , Marie-Christine Vantyghem , Anne Munck , Nathalie Wizla , Sylvie Leroy , Guy-André Loeuille , Raphaël Serreau , Fawzia Aissat , Gabriela H Thalhammer , Isidor Huttegger , Irmgard Eichler , Manfred Götz

As survival among patients with cystic fibrosis has improved in recent decades, complications have become increasingly relevant. The most frequent complication is cystic-fibrosis-related diabetes. The recommended treatment is injected insulin, but some patients are treated with oral antidiabetic drugs to ease the treatment burden. We assessed the efficacy and safety of oral antidiabetic drugs.

中文翻译:

瑞格列奈与胰岛素治疗囊性纤维化患者的新诊断糖尿病:一项多中心,开放标签,随机试验。

随着近几十年来囊性纤维化患者生存率的提高,并发症变得越来越重要。最常见的并发症是与囊性纤维化相关的糖尿病。推荐的治疗方法是注射胰岛素,但有些患者可以口服抗糖尿病药以减轻治疗负担。我们评估了口服降糖药的疗效和安全性。
更新日期:2018-01-24
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