Host–guest chemistry is exploited to tune the rate at which block copolymer vesicles undergo morphological transitions. More specifically, a concentrated aqueous dispersion of poly(glycerol monomethacrylate-co-glycidyl methacrylate)–poly(2-hydroxypropyl methacrylate) [P(GMA-co-GlyMA)-PHPMA] diblock copolymer vesicles was prepared via polymerization-induced self-assembly (PISA). The epoxy groups in the GlyMA residues were ring-opened using a primary amine-functionalized β-cyclodextrin (NH₂-β-CD) in order to prepare β-CD-decorated vesicles. Addition of azobenzene-methoxypoly(ethylene glycol) (azo-mPEG) to such vesicles results in specific binding of this water-soluble macromolecular reagent to the β-CD groups on the hydrophilic P(GMA-co-GlyMA) stabilizer chains. Such host–guest chemistry induces a morphological transition from vesicles to worms and/or spheres. Furthermore, the rate of this morphological transition can be tuned by UV/visible-light irradiation and/or guest molecule competition. This novel molecular recognition strategy offers considerable scope for the design of new stimulus-responsive diblock copolymer vesicles for targeted delivery and controlled release of cargoes.

中文翻译：

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使用主客体化学调节嵌段共聚物囊泡的形态转变动力学

利用主客体化学来调节嵌段共聚物囊泡经历形态转变的速率。更具体地说，通过聚合诱导的自组装制备聚（单甲基丙烯酸甘油酯-共-甲基丙烯酸缩水甘油酯）-聚（甲基丙烯酸2-羟丙酯）[P(GMA- co -GlyMA)-PHPMA]二嵌段共聚物囊泡的浓缩水分散体（比萨）。GlyMA 残基中的环氧基团使用伯胺官能化的 β-环糊精 (NH ₂ -β-CD) 开环以制备 β-CD 修饰的囊泡。将偶氮苯-甲氧基聚（乙二醇）（azo-mPEG）添加到此类囊泡中会导致这种水溶性大分子试剂与亲水性 P(GMA- co ) 上的 β-CD 基团特异性结合。-GlyMA) 稳定剂链。这种主客体化学诱导了从囊泡到蠕虫和/或球体的形态转变。此外，这种形态转变的速率可以通过紫外/可见光照射和/或客体分子竞争来调节。这种新颖的分子识别策略为设计新的刺激响应二嵌段共聚物囊泡提供了相当大的空间，用于靶向递送和控制释放货物。