Design and Application of a DNA-Encoded Macrocyclic Peptide Library,ACS Chemical Biology

当前位置： X-MOL 学术 › ACS Chem. Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Design and Application of a DNA-Encoded Macrocyclic Peptide Library
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2017-12-04 00:00:00 , DOI: 10.1021/acschembio.7b00852
Zhengrong Zhu ₁ , Alex Shaginian ₁ , LaShadric C. Grady ₁ , Thomas O’Keeffe ₁ , Xiangguo E. Shi ₁ , Christopher P. Davie ₁ , Graham L. Simpson ₂ , Jeffrey A. Messer ₁ , Ghotas Evindar ₁ , Robert N. Bream ₂ , Praew P. Thansandote ₂ , Naomi R. Prentice ₂ , Andrew M. Mason ₂ , Sandeep Pal ₂

Affiliation

A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 10¹² members composed of 4–20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.

中文翻译：