Recently,ionic liquids (ILs) functionalized cyclodextrins (CDs) have attracted more and more attention in the fields of enantioseparation. In this study, a novel IL amino triazolium functionalized β-CD derivative, mono-6-deoxy-6-(4-amino-1,2,4-triazolium)-β-cyclodextrin chloride (4-ATMCDCl), was synthesized for the first time and managed to separate dansyl amino acids and naproxen by capillary electrophoresis (CE). Compared with native β-CD, the new selector exhibited good water solubility and enhanced enantioselectivity. Several crucial parameters such as selector concentration, buffer pH, and applied voltage were systematically investigated. The molecular docking program Autodock was applied to further demonstrate the mechanism of chiral recognition and the enhanced enantioselectivity of 4-ATMCDCl, which showed good agreement with our experimental results.

近来，在对映体分离领域中，离子液体（IL）官能化的环糊精（CD）已引起越来越多的关注。在这项研究中，合成了一种新的IL氨基三唑官能化的β-CD衍生物，即单-6-脱氧-6-（4-氨基-1,2,4-三唑鎓）-β-环糊精氯化物（4-ATMCDCl）。首次成功地通过毛细管电泳（CE）分离了丹酰氨基酸和萘普生。与天然β-CD相比，新型选择剂显示出良好的水溶性和增强的对映选择性。系统地研究了几个关键参数，例如选择剂浓度，缓冲液pH和施加电压。应用分子对接程序Autodock进一步证明了手性识别的机理和4-ATMCDCl增强的对映选择性，