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Pulmonary drug delivery to older people
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2017-11-29 , DOI: 10.1016/j.addr.2017.11.010
Martin Wallin , Tatsuaki Tagami , Lan Chen , Mingshi Yang , Hak-Kim Chan

Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are common in older people. Treatment principles are well established in this group of patients; however, inadequate training and improper inhaler techniques often results in poor treatment outcomes. Healthcare professionals often do not have the required knowledge about the most common inhaler devices. Age-related conditions like cognitive ability and physical strength would also impact on the inhaler usage. Pharmacokinetics and pharmacodynamics may be affected by physiological changes, like impaired renal and hepatic functions and reduced lung functions. Adjusting and optimizing the inhaler device to the patient preferences, improvement of the drug formulation and inhalers, and using different adherence strategies might improve the treatment outcomes in elderly patients.



中文翻译:

向老年人提供肺部药物

肺部疾病,例如哮喘和慢性阻塞性肺疾病(COPD),在老年人中很常见。该组患者的治疗原则已经确立。但是,培训不足和吸入器技术不当通常会导致治疗效果不佳。医疗保健专业人员通常没有最常见的吸入器设备所需的知识。与年龄有关的状况,例如认知能力和体力也会影响吸入器的使用。药代动力学和药效学可能会受到生理变化的影响,例如肾和肝功能受损和肺功能降低。根据患者喜好调整和优化吸入器设备,改善药物配方和吸入器,

更新日期:2017-11-29
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