Water-soluble, nano-sized crosslinked polymer networks, or nanogels, are delivery vehicles, which have highly interesting properties for therapeutic delivery and imaging. Nanogels may also possess responsive properties, depending on the employed polymers, allowing controlled release of therapeutics or image contrast generation upon exposure to physical or (bio)chemical cues. In this review, polymer nanogels are explored for application in imaging as well as for controlled drug and gene delivery. Moreover, nanogels are explored as responsive biomaterials and future applications are highlighted.

中文翻译：

---

用于成像和治疗的响应性交联聚合物纳米凝胶

水溶性，纳米尺寸的交联聚合物网络或纳米凝胶是递送载体，其对于治疗性递送和成像具有非常令人感兴趣的特性。取决于所使用的聚合物，纳米凝胶还可以具有响应特性，从而允许在暴露于物理或（生物）化学线索时控制释放治疗剂或产生图像对比。在这篇综述中，聚合物纳米凝胶被研究用于成像以及可控的药物和基因递送。此外，纳米凝胶已被研究为可响应的生物材料，并着重指出了其未来的应用。