Ligand‐Assisted Pd‐Catalyzed N‐Dealkylative Carbonylation of Tertiary Amines with (Hetero)Aryl Halides to Tertiary Amides,Asian Journal of Organic Chemistry

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Ligand‐Assisted Pd‐Catalyzed N‐Dealkylative Carbonylation of Tertiary Amines with (Hetero)Aryl Halides to Tertiary Amides
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-12-06 , DOI: 10.1002/ajoc.201700574
Rajendra S. Mane ₁ , Bhalchandra M. Bhanage ₁

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This work reports an efficient synthesis of tertiary amides using a ligand‐assisted Pd‐catalyzed carbonylation of (hetero)aryl halides with tertiary amines. A key step in this reaction is C(sp³)−N bond cleavage using CuO as an oxidant. The reaction proceeds with high efficiency employing a bidentate phosphine ligand (dppp), which is a key for the carbonylation of unreactive (hetero)aryl halides and series of tertiary amines at atmospheric pressure of carbon monoxide.

中文翻译：

配体辅助的Pd催化的叔胺与（杂）芳基卤化物的叔胺的N-脱烷基羰基化反应生成叔酰胺

这项工作报告了使用叔胺与配位体辅助的Pd催化的（杂）芳基卤化物的羰基化羰基反应，可以有效地合成叔酰胺。该反应的关键步骤是使用CuO作为氧化剂裂解C（sp ³）-N键。该反应使用二齿膦配体（dppp）以高效率进行，这是在一氧化碳的大气压下将未反应的（杂）芳基卤化物和一系列叔胺羰基化的关键。

更新日期：2017-12-06

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