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Clustering of Rac1: Selective Lipid Sorting Drives Signaling
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2017-11-30 , DOI: 10.1016/j.tibs.2017.11.007 Kelsey N. Maxwell , Yong Zhou , John F. Hancock
中文翻译:
Rac1的群集:选择性脂质分类驱动信号。
更新日期:2017-11-30
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2017-11-30 , DOI: 10.1016/j.tibs.2017.11.007 Kelsey N. Maxwell , Yong Zhou , John F. Hancock
The ability of lipid-anchored small GTPases to form nanometer-scale lipid domains on the cell plasma membrane (PM) is precipitating exciting new insights into membrane-anchored protein regulation. A recent article by Remorino et al. demonstrates that Rac1, similar to Ras, forms nanoclusters on the PM. The implications of these findings are discussed herein.
中文翻译:
Rac1的群集:选择性脂质分类驱动信号。
脂质锚定的小GTP酶在细胞质膜(PM)上形成纳米级脂质结构域的能力正在为膜锚定的蛋白质调控提供令人振奋的新见解。Remorino等人的最新文章。证明Rac1与Ras类似,在PM上形成纳米团簇。这些发现的含义在本文中讨论。