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Mining for Small Translated ORFs
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2017-12-11 00:00:00 , DOI: 10.1021/acs.jproteome.7b00707 Anastasia Chugunova 1, 2 , Tsimafei Navalayeu 1 , Olga Dontsova 1, 2 , Petr Sergiev 1, 2
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2017-12-11 00:00:00 , DOI: 10.1021/acs.jproteome.7b00707 Anastasia Chugunova 1, 2 , Tsimafei Navalayeu 1 , Olga Dontsova 1, 2 , Petr Sergiev 1, 2
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Peptides encoded by short open reading frames (sORFs) are usually defined as peptides ≤100 aa long. Usually sORFs were ignored by automatic genome annotation programs due to the high probability of false discovery. However, improved computational tools along with a high-throughput RIBO-seq approach identified a myriad of translated sORFs. Their importance becomes evident as we are gaining experimental validation of their diverse cellular functions. This Review examines various computational and experimental approaches of sORFs identification as well as provides the summary of our current knowledge of their functional roles in cells.
中文翻译：
小型翻译ORF的挖掘
由短开放阅读框（sORF）编码的肽通常定义为≤100 aa长的肽。通常，由于错误发现的可能性很高，自动基因组注释程序会忽略sORF。但是，改进的计算工具以及高通量的RIBO-seq方法可识别无数翻译的sORF。随着我们对它们的多种细胞功能的实验验证，它们的重要性变得显而易见。这篇评论检查了sORFs鉴定的各种计算和实验方法，并提供了我们目前对它们在细胞中的功能作用的认识的总结。
更新日期：2017-12-11
中文翻译：
小型翻译ORF的挖掘
由短开放阅读框（sORF）编码的肽通常定义为≤100 aa长的肽。通常，由于错误发现的可能性很高，自动基因组注释程序会忽略sORF。但是，改进的计算工具以及高通量的RIBO-seq方法可识别无数翻译的sORF。随着我们对它们的多种细胞功能的实验验证，它们的重要性变得显而易见。这篇评论检查了sORFs鉴定的各种计算和实验方法，并提供了我们目前对它们在细胞中的功能作用的认识的总结。
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