Unravelling the Carbohydrate‐Binding Preferences of the Carbohydrate‐Binding Modules of AMP‐Activated Protein Kinase,ChemBioChem

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Unravelling the Carbohydrate‐Binding Preferences of the Carbohydrate‐Binding Modules of AMP‐Activated Protein Kinase
ChemBioChem ( IF 2.6 ) Pub Date : 2018-01-09 , DOI: 10.1002/cbic.201700589
Jesse I. Mobbs _{1,

2,

3} , Alex Di Paolo _{1,

2,

4} , Riley D. Metcalfe _{1,

2} , Emily Selig _{1,

2} , David I. Stapleton _{1,

2} , Michael D. W. Griffin _{1,

2} , Paul R. Gooley _{1,

2}

Affiliation

Ancient conservation: The β subunit of adenosine monophosphate (AMP)‐activated protein kinase, which exists as two isoforms (β1 and β2) in humans, has a carbohydrate‐binding module that interacts with glycogen. Investigations through ancestral sequence reconstruction and mutagenesis reveal conserved residues for carbohydrate binding.