Characterisation of a Bacterial Galactokinase with High Activity and Broad Substrate Tolerance for Chemoenzymatic Synthesis of 6‐Aminogalactose‐1‐Phosphate and Analogues,ChemBioChem

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Characterisation of a Bacterial Galactokinase with High Activity and Broad Substrate Tolerance for Chemoenzymatic Synthesis of 6‐Aminogalactose‐1‐Phosphate and Analogues
ChemBioChem ( IF 2.6 ) Pub Date : 2018-01-04 , DOI: 10.1002/cbic.201700477
Kun Huang ₁ , Fabio Parmeggiani ₁ , Edward Pallister ₁ , Chuen-Jiuan Huang ₁ , Fang-Fang Liu ₂ , Qian Li ₂ , William R. Birmingham ₁ , Peter Both ₁ , Baptiste Thomas ₁ , Li Liu ₂ , Josef Voglmeir ₂ , Sabine L. Flitsch ₁

Affiliation

Furnishing phosphates: A galactokinase from L. grimontii (LgGalK) has been identified and characterised; it shows broad substrate specificity towards different nucleotide phosphates and monosaccharides. This enzyme, in combination with a galactose oxidase variant was used in the chemoenzymatic synthesis of a panel of 6‐aminogalactose‐1‐phosphate analogues.

中文翻译：

具有化学活性的6-氨基半乳糖-1-磷酸盐及其类似物化学合成的高活性细菌半乳糖激酶的表征

提供磷酸盐：已经鉴定并鉴定了来自格氏乳杆菌的半乳糖激酶（LgGalK）；它对不同的核苷酸磷酸和单糖显示出广泛的底物特异性。该酶与半乳糖氧化酶变体结合在一起，用于化学酶合成6-氨基半乳糖-1-磷酸类似物。

更新日期：2018-01-04

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