Synthesis of biologically active boron-containing compounds†,RSC Medicinal Chemistry

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Synthesis of biologically active boron-containing compounds†
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2017-11-28 00:00:00 , DOI: 10.1039/c7md00552k
Fei Yang _{1,

2,

3,

4,

5} , Mingyan Zhu _{1,

2,

3,

4,

5} , Jinyi Zhang _{1,

2,

3,

4,

5} , Huchen Zhou _{1,

2,

3,

4,

5}

Affiliation

Boron-containing compounds which possess unique and attractive properties have received increasing attention from the pharmaceutical industry and academia recently. They have shown interesting and useful biological activities, including antibacterial, antifungal, antiparasitic, antiviral, and anti-inflammatory activities. In this review, the synthetic strategies for various boron-containing compounds, including peptidyl boronic acids, benzoxaboroles, benzoxaborines, benzodiazaborines, amine carboxyboranes, and amine cyanoboranes are summarized. Representative structures of each structural class and recently developed biologically active boron-containing compounds are used as examples in this review.

中文翻译：

具有生物活性的含硼化合物的合成†

具有独特和吸引人的性能的含硼化合物近来受到制药工业和学术界的越来越多的关注。它们显示出有趣且有用的生物学活性，包括抗菌，抗真菌，抗寄生虫，抗病毒和抗炎活性。在这篇综述中，总结了各种含硼化合物的合成策略，包括肽基硼酸，苯并硼硼烷，苯并氧杂硼烷，苯并二氮硼硼烷，胺基羧基硼烷和胺基氰基硼烷。每个结构类别的代表性结构以及最近开发的具有生物活性的含硼化合物均作为本综述的实例。

更新日期：2017-11-28

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