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ESMO Consensus Conference on malignant lymphoma: general perspectives and recommendations for the clinical management of the elderly patient with malignant lymphoma.
Annals of Oncology ( IF 50.5 ) Pub Date : 2018-03-01 , DOI: 10.1093/annonc/mdx413
C Buske 1 , M Hutchings 2 , M Ladetto 3 , V Goede 4 , U Mey 5 , P Soubeyran 6 , M Spina 7 , R Stauder 8 , M Trněný 9 , U Wedding 10 , P Fields 11 ,
Affiliation  

The European Society for Medical Oncology (ESMO) consensus conference on mature B cell lymphomas and chronic lymphocytic leukaemia (CLL) was held on 20 June 2015 in Lugano, Switzerland, and included a multidisciplinary panel of 25 leading experts. The aim of the conference was to develop recommendations on critical subjects difficult to consider in detail in the ESMO Clinical Practice Guidelines. The following areas were identified: (1) the elderly patient, (2) prognostic factors suitable for clinical use, and (3) the 'ultra-high-risk' group. Before the conference, the expert panel was divided into three working groups; each group focused on one of these areas in order to address clinically-relevant questions relating to that topic. All relevant scientific literature, as identified by the experts, was reviewed in advance. During the consensus conference, each working group developed recommendations to address each of the four questions assigned to their group. These recommendations were presented to the entire panel and a consensus was reached. This consensus, which was further developed in continuous post-meeting discussions, formed the basis of three manuscripts, each covering one of the three key areas identified. This manuscript presents the consensus recommendations regarding the clinical management of elderly patients diagnosed with malignant lymphoma. Four clinically-relevant topics identified by the panel were: 1) how to define patient fitness, 2) assessing quality of life, 3) diagnostic work-up and 4) clinical management of elderly patients with lymphoma. Each of these key topics is addressed in the context of five different lymphoma entities, namely: CLL, follicular lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma and diffuse large B-cell lymphoma. Results, including a summary of evidence supporting each recommendation, are detailed in this manuscript.

中文翻译:

ESMO恶性淋巴瘤共识会议:老年恶性淋巴瘤患者临床治疗的一般观点和建议。

关于成熟B细胞淋巴瘤和慢性淋巴细胞性白血病(CLL)的欧洲医学肿瘤学会(ESMO)共识会议于2015年6月20日在瑞士卢加诺举行,由25名知名专家组成的多学科小组参加了会议。这次会议的目的是针对关键主题制定建议,这些建议很难在《 ESMO临床实践指南》中详细考虑。确定了以下领域:(1)老年患者,(2)适合临床使用的预后因素,以及(3)“超高风险”组。会议之前,专家小组分为三个工作组:每个小组都专注于这些领域之一,以解决与该主题相关的临床相关问题。专家确认了所有相关的科学文献,这些都是预先审查过的。在共识会议期间,每个工作组都提出了建议,以解决分配给其小组的四个问题中的每个问题。这些建议已提交给整个小组,并达成了共识。这种共识在会后的持续讨论中得到了进一步发展,形成了三份手稿的基础,每份手稿涵盖了所确定的三个关键领域之一。该手稿提出了关于诊断为恶性淋巴瘤的老年患者的临床治疗的共识性建议。专家组确定了四个与临床相关的主题:1)如何定义患者的健康状况; 2)评估生活质量; 3)诊断性检查; 4)老年淋巴瘤患者的临床管理。在五个不同的淋巴瘤实体(即CLL,滤泡性淋巴瘤,套细胞淋巴瘤,外周T细胞淋巴瘤和弥漫性大B细胞淋巴瘤。该手稿详细介绍了结果,包括支持每个建议的证据摘要。
更新日期:2017-11-29
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