EXOPLEXs: Chimeric Drug Delivery Platform from the Fusion of Cell-Derived Nanovesicles and Liposomes,Biomacromolecules

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EXOPLEXs: Chimeric Drug Delivery Platform from the Fusion of Cell-Derived Nanovesicles and Liposomes
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-12-08 00:00:00 , DOI: 10.1021/acs.biomac.7b01176
Wei Jiang Goh _{1,

2} , Shui Zou ₂ , Choon Keong Lee ₂ , Yi-Hsuan Ou ₂ , Jiong-Wei Wang _{3,

4} , Bertrand Czarny ₂ , Giorgia Pastorin _{1,

2,

5}

Affiliation

Cell-derived nanovesicles (CDNs) have been recently investigated as novel drug delivery systems (DDSs), due to the preservation of key features from the cell membrane of their precursor cells, which are responsible for an efficient cellular uptake by target cells. However, CDNs suffer from low drug loading efficiencies as well as challenges in functionalization compared to conventional DDS like liposomes. Here, we describe the first study proposing the fusion of CDNs with liposomes to form EXOPLEXs. We report the preservation of cell membranes from precursor cells similarly to CDNs, as well as high loading efficiencies of more than 65% with doxorubicin hydrochloride, a model chemotherapeutic drug. The doxorubicin-loaded EXOPLEXs (DOX-EXO) also demonstrated a higher in vitro cell killing effect than liposomes, while EXOPLEXs alone did not show any remarkable cytotoxicity. Taken together, these results illustrate the potential of EXOPLEXs as a novel DDS for targeted delivery of chemotherapeutics.

中文翻译：

EXOPLEXs：细胞衍生的纳米囊泡和脂质体融合的嵌合药物递送平台

由于保留了其前体细胞的细胞膜中的关键特征，这些特征负责靶细胞的有效细胞吸收，因此最近已研究了细胞衍生的纳米囊泡（CDN）作为新型药物传递系统（DDS）。但是，与传统的DDS（如脂质体）相比，CDN的载药效率低，并且在功能化方面面临挑战。在这里，我们描述了第一个提出CDN与脂质体融合形成EXOPLEX的研究。我们报道了类似于CDNs的前体细胞细胞膜的保存，以及使用阿霉素盐酸盐（一种模型化学治疗药物）的超过65％的高负载效率。载有阿霉素的EXOPLEXs（DOX-EXO）在体外也表现出更高的脂质体对细胞的杀伤作用比脂质体高，而单独的EXOPLEXs并没有表现出任何明显的细胞毒性。综上所述，这些结果说明了EXOPLEXs作为靶向治疗药物的新型DDS的潜力。

更新日期：2017-12-08

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