Membrane Crossing and Membranotropic Activity of Cell-Penetrating Peptides: Dangerous Liaisons?,Accounts of Chemical Research

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Membrane Crossing and Membranotropic Activity of Cell-Penetrating Peptides: Dangerous Liaisons?
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-11-27 00:00:00 , DOI: 10.1021/acs.accounts.7b00455
Astrid Walrant ₁ , Sébastien Cardon ₁ , Fabienne Burlina ₁ , Sandrine Sagan ₁

Affiliation

Living organisms have to maintain a stable balance in molecules and ions in the changing environment in which they are living, a process known as homeostasis. At the level of cells, the plasma membrane has a major role in homeostasis, since this hydrophobic film prevents passive diffusion of large and hydrophilic molecules between the extracellular and intracellular milieu. Living organisms have evolved with highly sophisticated transport systems to control exchanges across this barrier: import of nutrients and fuel essential for their survival; recognition of chemical or physical messengers allowing information interchanges with surrounding cells. Besides specialized proteins, endocytosis mechanisms at the level of the lipid bilayer can transport molecules from the outside across the cell membrane, in an energy-dependent manner.

中文翻译：

细胞穿透肽的膜交叉和膜活性：危险的联系？

生命有机体必须在不断变化的环境中保持分子和离子的稳定平衡，这一过程称为体内平衡。在细胞水平上，质膜在稳态中起主要作用，因为该疏水膜可防止大的亲水分子在细胞外和细胞内环境之间的被动扩散。生命有机体已经发展成为具有高度复杂的运输系统，可以控制跨越这一障碍的交换：营养物质和燃料的进口对它们的生存至关重要；识别化学或物理信使，允许与周围细胞交换信息。除了专门的蛋白质外，脂质双层水平上的内吞作用机制还可以以能量依赖的方式将分子从外部转运到整个细胞膜上。

更新日期：2017-11-27

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