Abstract

Phosphorus-substituted quaternary carbon stereocenters exist widely in drugs and biologically active compounds. Catalytic asymmetric synthesis of such quaternary carbon stereogenic centers is of significant importance, with four synthetic strategies being established. This review summarizes the recent progress in this field, including the advantages and limitations of each strategy, briefly discusses the reaction mechanisms and challenges, and outlines synthetic opportunities still open.

1 Introduction

2 Asymmetric Hydrophosphonylation

3 Asymmetric Electrophilic Phosphination

4 Asymmetric Functionalization of P-Substituted Methine Compounds

5 Asymmetric Addition to α-Keto- or α-Ketiminophosphonates

6 Conclusion

Phosphorus-substituted quaternary carbon stereocenters exist widely in drugs and biologically active compounds. Catalytic asymmetric synthesis of such quaternary carbon stereogenic centers is of significant importance, with four synthetic strategies being established. This review summarizes the recent progress in this field, including the advantages and limitations of each strategy, briefly discusses the reaction mechanisms and challenges, and outlines synthetic opportunities still open.

1 Introduction

2 Asymmetric Hydrophosphonylation

3 Asymmetric Electrophilic Phosphination

4 Asymmetric Functionalization of P-Substituted Methine Compounds

5 Asymmetric Addition to α-Keto- or α-Ketiminophosphonates

6 Conclusion

中文翻译：

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磷取代的季碳立体中心催化不对称结构的最新研究进展

摘要

磷取代的季碳立体中心广泛存在于药物和生物活性化合物中。这种季碳立体异构中心的催化不对称合成具有重要意义，目前已建立了四种合成策略。这篇综述总结了该领域的最新进展，包括每种策略的优点和局限性，简要讨论了反应机制和挑战，并概述了仍然存在的综合机会。

1引言

2不对称氢膦酰化

3不对称亲电磷酸化

4 P取代的甲硫氨酸化合物的不对称官能化

5α-酮基或α-酮亚氨基膦酸酯的不对称加成

六，结论

磷取代的季碳立体中心广泛存在于药物和生物活性化合物中。这种季碳立体异构中心的催化不对称合成具有重要意义，目前已建立了四种合成策略。这篇综述总结了该领域的最新进展，包括每种策略的优点和局限性，简要讨论了反应机制和挑战，并概述了仍然存在的综合机会。

1引言

2不对称氢膦酰化

3不对称亲电磷酸化

4 P取代的甲硫氨酸化合物的不对称官能化

5α-酮基或α-酮亚氨基膦酸酯的不对称加成

六，结论