The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial for transducing signals from a variety of metabolically relevant hormones and cytokines including growth hormone, leptin, erythropoietin, IL4, IL6 and IFNγ. A growing body of evidence suggests that this pathway is dysregulated in the context of obesity and metabolic disease. Recent development of animal models has been instrumental in identifying the role of JAK/STAT signaling in the peripheral metabolic organs including adipose, liver, muscle, pancreas, and the immune system. In this review we summarize current knowledge about the function of JAK/STAT proteins in the regulation of metabolism, and highlight new potential therapeutic targets for the treatment of obesity and diabetes.

中文翻译：

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JAK/STAT – 代谢领域的新兴参与者

Janus 激酶 (JAK)/信号转导和转录激活因子 (STAT) 通路对于转导来自各种代谢相关激素和细胞因子的信号至关重要，包括生长激素、瘦素、促红细胞生成素、IL4、IL6 和 IFNγ。越来越多的证据表明，该途径在肥胖和代谢疾病的背景下失调。动物模型的最新发展有助于确定 JAK/STAT 信号在外周代谢器官（包括脂肪、肝脏、肌肉、胰腺和免疫系统）中的作用。在这篇综述中，我们总结了目前关于 JAK/STAT 蛋白在代谢调节中的功能的知识，并强调了治疗肥胖和糖尿病的新潜在治疗靶点。