Controlling the Size of Two-Dimensional Polymer Platelets for Water-in-Water Emulsifiers,ACS Central Science

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Controlling the Size of Two-Dimensional Polymer Platelets for Water-in-Water Emulsifiers
ACS Central Science ( IF 12.7 ) Pub Date : 2017-11-27 00:00:00 , DOI: 10.1021/acscentsci.7b00436
Maria Inam ₁ , Joseph R Jones ₁ , Maria M Pérez-Madrigal ₁ , Maria C Arno ₁ , Andrew P Dove ₁ , Rachel K O'Reilly ₁

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A wide range of biorelevant applications, particularly in pharmaceutical formulations and the food and cosmetic industries, require the stabilization of two water-soluble blended components which would otherwise form incompatible biphasic mixtures. Such water-in-water emulsions can be achieved using Pickering stabilization, where two-dimensional (2D) nanomaterials are particularly effective due to their high surface area. However, control over the shape and size of the 2D nanomaterials is challenging, where it has not yet been possible to examine chemically identical nanostructures with the same thickness but different surface areas to probe the size-effect on emulsion stabilization ability. Hence, the rationale design and realization of the full potential of Pickering water-in-water emulsion stabilization have not yet been achieved. Herein, we report for the first time 2D poly(lactide) platelets with tunable sizes (with varying coronal chemistry) and of uniform shape using a crystallization-driven self-assembly methodology. We have used this series of nanostructures to explore the effect of 2D platelet size and chemistry on the stabilization of a water-in-water emulsion of a poly(ethylene glycol) (PEG)/dextran mixture. We have demonstrated that cationic, zwitterionic, and neutral large platelets (ca. 3.7 × 10⁶ nm²) all attain smaller droplet sizes and more stable emulsions than their respective smaller platelets (ca. 1.2 × 10⁵ nm²). This series of 2D platelets of controlled dimensions provides an excellent exemplar system for the investigation of the effect of just the surface area on the potential effectiveness in a particular application.

中文翻译：

控制水包水乳化剂二维聚合物片的尺寸

广泛的生物相关应用，特别是在药物制剂以及食品和化妆品行业，需要稳定两种水溶性混合组分，否则会形成不相容的双相混合物。这种水包水乳液可以使用皮克林稳定法来实现，其中二维（2D）纳米材料由于其高表面积而特别有效。然而，控制二维纳米材料的形状和尺寸具有挑战性，目前还无法检查具有相同厚度但不同表面积的化学相同的纳米结构，以探讨尺寸对乳液稳定能力的影响。因此，皮克林水包水乳液稳定性的全部潜力尚未实现合理设计和实现。在此，我们首次使用结晶驱动的自组装方法报告了具有可调尺寸（具有不同的冠状化学）和均匀形状的二维聚（丙交酯）血小板。我们使用这一系列纳米结构来探索 2D 片晶尺寸和化学性质对聚乙二醇 (PEG)/葡聚糖混合物的水包水乳液稳定性的影响。我们已经证明，阳离子、两性离子和中性大片晶（约 3.7 × 10 ⁶ nm ² ）都比各自的较小片晶（约 1.2 × 10 ⁵ nm ² ）获得更小的液滴尺寸和更稳定的乳液。这一系列尺寸受控的二维薄片为研究特定应用中表面积对潜在有效性的影响提供了一个极好的示例系统。

更新日期：2017-11-27

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