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Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba
Journal of Natural Products ( IF 5.1 ) Pub Date : 2017-11-27 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00679
Allan Patrick G. Macabeo 1 , Arianne G. Letada 1 , Simon Budde 2 , Christian Faderl 2 , Hans-Martin Dahse 3 , Scott G. Franzblau 4 , Grecebio Jonathan D. Alejandro 5 , Gregory K. Pierens , Mary J. Garson
Affiliation  

Two new chlorine-containing polyoxygenated seco-cyclohexenes, albanols A (1) and B (2), along with the oxepinone metabolite grandiuvarone (3) were isolated from the endemic Philippine Annonaceae plant Uvaria alba. Both new compounds exhibited modest antitubercular activity. Compound 1 showed cytostatic activity (ranging from 1–50 μM) against HeLa cells and weak antiproliferative activity against HUVEC and K-562 cells with GI50 values of 106 and 81 μM, respectively.

中文翻译:

抗结核和细胞毒性氯化塞科从-Cyclohexenes紫玉盘阿尔巴

两个新的多氧含氯开环-cyclohexenes,albanols A(1)和B(2),随着oxepinone代谢物grandiuvarone(3)从所述地方性菲番荔枝植物中分离紫玉盘粉。两种新化合物均显示出适度的抗结核活性。化合物1对HeLa细胞表现出细胞抑制活性(范围为1–50μM),对HUVEC和K-562细胞的抗增殖活性较弱,GI 50分别为106和81μM。
更新日期:2017-11-27
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