Single nanoparticle analysis by ICPMS: a potential tool for bioassay,Journal of Analytical Atomic Spectrometry

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Single nanoparticle analysis by ICPMS: a potential tool for bioassay
Journal of Analytical Atomic Spectrometry ( IF 3.1 ) Pub Date : 2017-11-13 00:00:00 , DOI: 10.1039/c7ja00235a
Jianyu Hu _{1,

2,

3,

4} , Dongyan Deng _{1,

2,

3,

4} , Rui Liu _{1,

2,

3,

4} , Yi Lv _{1,

2,

3,

4,

5}

Affiliation

Inductively coupled plasma mass spectrometry (ICPMS) has already been demonstrated as a promising technique for metallic nanoparticle tagged bioassays due to its high sensitivity, wide dynamic linear range, and more importantly multiplex and absolute quantification ability. Besides, single nanoparticle analysis by ICPMS has also recently been applied for many metal nanoparticles. Moreover, its short data acquisition dwell times (serval hundred microseconds) lead to an extremely high signal to noise ratio for metal nanoparticles (i.e., low detection limits). This perspective focuses on single nanoparticle analysis-based ICPMS bioassays, which provide high sensitivity without any sophisticated signal amplification procedures. Herein, the recent development of single nanoparticle analysis, ICPMS instrument design, and single molecule analysis is discussed. Considering the vast types of metallic nanoparticles currently available and simultaneous multiplex detection capability of TOF-ICPMS, single nanoparticle analysis-based bioassays may open a new avenue for multiplex single molecule analysis.

中文翻译：

ICPMS进行单个纳米颗粒分析：生物测定的潜在工具

电感耦合等离子体质谱法（ICPMS）具有高灵敏度，宽动态线性范围以及更重要的是多重分析和绝对定量分析能力，因此已被证明是一种用于金属纳米颗粒标记生物测定的有前途的技术。此外，最近通过ICPMS进行的单纳米颗粒分析也已应用于许多金属纳米颗粒。此外，其短的数据采集停留时间（约百微秒）导致金属纳米粒子的信噪比极高（即，检测限低）。该观点侧重于基于单纳米颗粒分析的ICPMS生物测定，该测定无需任何复杂的信号放大程序即可提供高灵敏度。在此，讨论了单纳米颗粒分析，ICPMS仪器设计和单分子分析的最新进展。考虑到当前可用的金属纳米颗粒的种类繁多以及TOF-ICPMS的同时多重检测能力，基于单纳米颗粒分析的生物测定法可能会为多重单分子分析开辟新的途径。

更新日期：2017-11-28

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