Spatial Patterning of Hydrogels via 3D Covalent Transfer Stamping from a Fugitive Ink,Macromolecular Rapid Communications

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Spatial Patterning of Hydrogels via 3D Covalent Transfer Stamping from a Fugitive Ink
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2017-11-24 , DOI: 10.1002/marc.201700564
Shuang Wang _{1,

2} , Paul D. Dalton ₃ , Tim R. Dargaville _{1,

2}

Affiliation

In this study, a novel hydrogel patterning approach using 3D covalent transfer stamping from a fugitive ink is introduced. A model transfer molecule (7‐diethylamino‐3‐(4′maleimidylphenyl)‐4‐methylcoumarin (CPM)) is absorbed into a 3D fugitive ink stamp made from poly(caprolactone), and then encapsulated in a poly(ethylene glycol) hydrogel. As the CPM diffuses from the fugitive ink to the curing hydrogel it is selectively covalently bound at the boundary of the ink and the hydrogel. Removal of the fugitive ink by solvent exchange leads to a negative copy of interconnected channels patterned with the localized transfer of the molecules at the hydrogel interface. The results suggest that small molecules can be patterned in porous hydrogels in a spatially controllable manner and that the transferred amount can be tuned.

中文翻译：

通过3D共价转移印花从逃犯墨水的水凝胶的空间图案。

在这项研究中，介绍了一种新型的水凝胶图案化方法，该方法使用了来自逃犯性墨水的3D共价转移压印。模型转移分子（7-二乙氨基-3-（4′-马来酰亚胺基苯基）-4-甲基香豆素（CPM））被吸收到由聚己内酯制成的3D逃犯印章中，然后封装在聚乙二醇水凝胶中。当CPM从短效油墨扩散到固化的水凝胶时，它选择性地共价键合在油墨和水凝胶的边界上。通过溶剂交换去除短效油墨会导致相互连通的通道产生负向复制，这些通道会在水凝胶界面处分子的局部转移上形成图案。结果表明，小分子可以以空间可控的方式在多孔水凝胶中形成图案，并且可以调节转移量。

更新日期：2017-11-24

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