Synthesis ( IF 2.6 ) Pub Date : 2017-11-23 , DOI: 10.1055/s-0036-1589136 Sabine Berteina-Raboin 1 , Joana Campos 1, 2 , Maria-João Queiroz 2
Abstract
New pyrazino[2′,3′:4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]-pyrimidin-5(4H)-ones were synthesized in an efficient, fast, and mild one-pot procedure from methyl 7-azidothieno[2,3-b]pyrazine-6-carboxylate. From the latter, some triazolothieno[2,3-b]pyrazine-6-carboxylates were also obtained with total regioselectivity by [2+3] cycloaddition with alkynes without any metal catalyst.
New pyrazino[2′,3′:4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]-pyrimidin-5(4H)-ones were synthesized in an efficient, fast, and mild one-pot procedure from methyl 7-azidothieno[2,3-b]pyrazine-6-carboxylate. From the latter, some triazolothieno[2,3-b]pyrazine-6-carboxylates were also obtained with total regioselectivity by [2+3] cycloaddition with alkynes without any metal catalyst.
中文翻译:
合成新的环状吡咯并噻吩并恶唑并吡啶并三唑基噻吩并吡嗪类化合物
摘要
合成了新的吡嗪并[2',3':4,5]噻吩并[2,3- e ] [1,2,3]三唑并[1,5 - a ]-嘧啶-5(4 H)-。 7-叠氮基[2,3 - b ]吡嗪-6-羧酸甲酯的高效,快速和温和的一锅法。从后者,还通过与炔烃的[2 + 3]环加成,在没有任何金属催化剂的情况下,以总区域选择性获得了一些三唑并[2,3 - b ]吡嗪-6-羧酸酯。
合成了新的吡嗪并[2',3':4,5]噻吩并[2,3- e ] [1,2,3]三唑并[1,5 - a ]-嘧啶-5(4 H)-。 7-叠氮基[2,3 - b ]吡嗪-6-羧酸甲酯的高效,快速和温和的一锅法。从后者,还通过与炔烃的[2 + 3]环加成,在没有任何金属催化剂的情况下,以总区域选择性获得了一些三唑并[2,3 - b ]吡嗪-6-羧酸酯。