An ultra-small thermosensitive nanocomposite with a Mo154-core as a comprehensive platform for NIR-triggered photothermal-chemotherapy†,Journal of Materials Chemistry B

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An ultra-small thermosensitive nanocomposite with a Mo154-core as a comprehensive platform for NIR-triggered photothermal-chemotherapy†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-11-24 00:00:00 , DOI: 10.1039/c7tb02743e
Simin Zhang _{1,

2,

3,

4,

5} , Haobin Chen _{3,

4,

5,

6,

7} , Guohua Zhang _{1,

2,

3,

4,

5} , Xueping Kong _{1,

2,

3,

4,

5} , Shengyan Yin _{3,

4,

5,

6,

7} , Bao Li _{1,

2,

3,

4,

5} , Lixin Wu _{1,

2,

3,

4,

5}

Affiliation

A uniform ultra-small (<10 nm) nanosized dendritic composite was reported for combined photothermal-chemotherapy, wherein a giant ring-like polymolybdate cluster was introduced for the first time as a photothermal therapeutic agent. The giant polyoxometalate cluster possesses strong absorption characteristics in the near infrared region, whereas it has never been applied for biomaterials due to its sensitivity towards environment and structural instability under physiological conditions. Herein, a cationic dendron bearing triethylene glycol monomethyl ether terminal groups was used to cover a giant polyanionic cluster Mo₁₅₄ surface through a simple electrostatic interaction. Arising from their assembly, the formed core–shell supramolecular composite that has uniform size, precise chemical composition and definite molecular weight not only exhibited mono-dispersion and low cytotoxicity, but also imparted anticancer drug loading and thermoresponsive properties, thus leading to NIR-controlled drug release. When irradiated with an 808 nm NIR laser, the formed complex had significant in vivo photothermal-chemotherapeutic effects on tumor tissue, which makes it a promising material for applications in nanomedicine.

中文翻译：

具有Mo ₁₅₄核的超小型热敏纳米复合材料，可作为近红外触发光热化学疗法的综合平台†

报道了一种均匀的超小（<10 nm）纳米尺寸的树枝状复合材料，用于联合光热化学疗法，其中首次引入了巨大的环状聚钼酸盐簇作为光热治疗剂。巨大的多金属氧酸盐簇在近红外区域具有很强的吸收特性，但由于其对环境的敏感性和在生理条件下的结构不稳定性，因此从未用于生物材料。在本文中，带有三乙二醇单甲醚端基的阳离子树枝状分子被用来覆盖一个巨大的聚阴离子簇Mo ₁₅₄表面通过简单的静电相互作用。由于其组装，形成的核-壳超分子复合物具有均匀的尺寸，精确的化学组成和确定的分子量，不仅表现出单分散性和低细胞毒性，而且还赋予了抗癌药物载量和热响应特性，因此可实现近红外控制药物释放。当用808 nm NIR激光照射时，形成的复合物对肿瘤组织具有显着的体内光热化学疗法作用，这使其成为用于纳米医学的有前途的材料。

更新日期：2017-11-24

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