Recent advances in the use of microfluidic technologies for single cell analysis,Analyst

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Recent advances in the use of microfluidic technologies for single cell analysis
Analyst ( IF 3.6 ) Pub Date : 2017-10-26 00:00:00 , DOI: 10.1039/c7an01346a
Travis W. Murphy _{1,

2,

3,

4} , Qiang Zhang _{1,

2,

3,

4} , Lynette B. Naler _{1,

2,

3,

4} , Sai Ma _{2,

3,

4,

5} , Chang Lu _{1,

2,

3,

4}

Affiliation

The inherent heterogeneity in cell populations has become of great interest and importance as analytical techniques have improved over the past decades. With the advent of personalized medicine, understanding the impact of this heterogeneity has become an important challenge for the research community. Many different microfluidic approaches with varying levels of throughput and resolution exist to study single cell activity. In this review, we take a broad view of the recent microfluidic developments in single cell analysis based on microwell, microchamber, and droplet platforms. We cover physical, chemical, and molecular biology approaches for cellular and molecular analysis including newly emerging genome-wide analysis.

中文翻译：

微流控技术用于单细胞分析的最新进展

随着分析技术在过去几十年中得到改进，细胞群体中固有的异质性已引起人们极大的兴趣和重要性。随着个性化医学的到来，了解这种异质性的影响已成为研究界的一项重要挑战。存在许多不同的通量和分辨率水平不同的微流体方法来研究单细胞活性。在这篇综述中，我们对基于微孔，微腔室和微滴平台的单细胞分析中微流控技术的最新发展进行了广泛的了解。我们涵盖用于细胞和分子分析的物理，化学和分子生物学方法，包括新兴的全基因组分析。

更新日期：2017-11-24

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