MINTbase is a repository that comprises nuclear and mitochondrial tRNA-derived fragments (‘tRFs’) found in multiple human tissues. The original version of MINTbase comprised tRFs obtained from 768 transcriptomic datasets. We used our deterministic and exhaustive tRF mining pipeline to process all of The Cancer Genome Atlas datasets (TCGA). We identified 23 413 tRFs with abundance of ≥ 1.0 reads-per-million (RPM). To facilitate further studies of tRFs by the community, we just released version 2.0 of MINTbase that contains information about 26 531 distinct human tRFs from 11 719 human datasets as of October 2017. Key new elements include: the ability to filter tRFs on-the-fly by minimum abundance thresholding; the ability to filter tRFs by tissue keywords; easy access to information about a tRF’s maximum abundance and the datasets that contain it; the ability to generate relative abundance plots for tRFs across cancer types and convert them into embeddable figures; MODOMICS information about modifications of the parental tRNA, etc. Version 2.0 of MINTbase contains 15x more datasets and nearly 4x more distinct tRFs than the original version, yet continues to offer fast, interactive access to its contents. Version 2.0 is available freely at http://cm.jefferson.edu/MINTbase/.

中文翻译：

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MINTbase v2.0：tRNA 衍生片段的综合数据库，包括来自所有癌症基因组图谱项目的核和线粒体片段


MINTbase 是一个存储库，包含在多个人体组织中发现的核和线粒体 tRNA 衍生片段 (“tRF”)。 MINTbase 的原始版本包含从 768 个转录组数据集中获得的 tRF。我们使用确定性和详尽的 tRF 挖掘管道来处理所有癌症基因组图谱数据集 (TCGA)。我们确定了 23 413 个 tRF，其丰度≥ 1.0 个每百万次读取 (RPM)。为了促进社区对 tRF 的进一步研究，我们刚刚发布了 MINTbase 2.0 版本，其中包含截至 2017 年 10 月来自 11,719 个人类数据集的 26,531 个不同人类 tRF 的信息。关键的新元素包括：按最小丰度阈值飞行；通过组织关键词过滤 tRF 的能力；轻松访问有关 tRF 最大丰度和包含该丰度的数据集的信息；能够生成跨癌症类型的 tRF 相对丰度图并将其转换为可嵌入的数字；有关亲代 tRNA 修改的 MODOMICS 信息等。MINTbase 2.0 版本包含比原始版本多 15 倍的数据集和近 4 倍的不同 tRF，但仍继续提供对其内容的快速、交互式访问。 2.0 版可在http://cm.jefferson.edu/MINTbase/上免费获取。