In this work, a simple desorption atmospheric pressure chemical ionization (SDAPCI) source is studied and optimized for analyzing a wide variety of samples such as nonvolatile, volatile and biological samples. In this ion source, the heated mass inlet was used for sample desorption, and a solid needle was used to produce a corona discharge for ionization. The utilization of any additional gas or heater is not required in SDAPCI. Due to its high sensitivity, only a small amount of sample is needed. Sample loading and the consequent mass spectrometry analysis process could be easy and fast, which was demonstrated by the analyses of different types of samples ranging from non-volatile to volatile compounds. High-throughput analysis can be performed by SDAPCI source with minimum or no sample preparation.

中文翻译：

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一种用于增强型非挥发性样品分析的简单解吸常压化学电离方法

在这项工作中，研究并优化了一个简单的解吸大气压化学电离 (SDAPCI) 源，以分析各种样品，例如非挥发性、挥发性和生物样品。在该离子源中，加热的质量入口用于解吸样品，并使用实心针产生电晕放电进行电离。SDAPCI 不需要使用任何额外的气体或加热器。由于其高灵敏度，只需要少量样品。样品加载和随后的质谱分析过程可以简单快捷，这通过对从非挥发性化合物到挥发性化合物的不同类型样品的分析得到证明。可以通过 SDAPCI 源进行高通量分析，只需最少或无需样品制备。