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Synthesis and Reactivity of Propargylamines in Organic Chemistry
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-11-22 00:00:00 , DOI: 10.1021/acs.chemrev.7b00343
Kate Lauder 1 , Anita Toscani 1 , Nicolò Scalacci 1 , Daniele Castagnolo 1
Affiliation  

Propargylamines are a versatile class of compounds which find broad application in many fields of chemistry. This review aims to describe the different strategies developed so far for the synthesis of propargylamines and their derivatives as well as to highlight their reactivity and use as building blocks in the synthesis of chemically relevant organic compounds. In the first part of the review, the different synthetic approaches to synthesize propargylamines, such as A3 couplings and C–H functionalization of alkynes, have been described and organized on the basis of the catalysts employed in the syntheses. Both racemic and enantioselective approaches have been reported. In the second part, an overview of the transformations of propargylamines into heterocyclic compounds such as pyrroles, pyridines, thiazoles, and oxazoles, as well as other relevant organic derivatives, is presented.

中文翻译:

炔丙胺在有机化学中的合成与反应性

炔丙胺是一类用途广泛的化合物,在许多化学领域中都有广泛的应用。这篇综述旨在描述迄今为止为炔丙基胺及其衍生物的合成开发的不同策略,并着重介绍它们的反应性以及在化学相关的有机化合物的合成中用作构建基块。在审查的第一部分中,合成炔丙基胺的不同合成方法,例如A 3炔烃的偶联和CH官能化已经在合成中使用的催化剂的基础上进行了描述和组织。已经报道了外消旋和对映选择性方法。在第二部分中,概述了炔丙基胺向杂环化合物(例如吡咯,吡啶,噻唑和恶唑)以及其他相关有机衍生物的转化。
更新日期:2017-11-22
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