Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive Manufacturing,Biomacromolecules

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Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive Manufacturing
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-12-04 00:00:00 , DOI: 10.1021/acs.biomac.7b01243
Xudong Deng ₁ , Rana Attalla , Lukas P. Sadowski , Mengsu Chen , Michael J. Majcher , Ivan Urosev , Da-Chuan Yin ₁ , P. Ravi Selvaganapathy , Carlos D. M. Filipe , Todd Hoare

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We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic cross-linking between 2-aminophenylboronic acid-functionalized hyaluronic acid and poly(vinyl alcohol) yields hydrogels that recover their mechanical integrity within 1 min after cutting or shear under both neutral and acidic pH conditions. Incorporation of this hydrogel in an interpenetrating calcium-alginate network results in an interfacially stiffer but still rapidly self-adhesive hydrogel that can be assembled into hollow perfusion channels by simple contact additive manufacturing within minutes. Such channels withstand fluid perfusion while retaining their dimensions and support endothelial cell growth and proliferation, providing a simple and modular route to produce customized cell scaffolds.

中文翻译：

自主自粘水凝胶作为增材制造的基础

我们报告了一种简单的方法，准备自治和快速的自粘水凝胶及其作为功能组织支架增材制造的基础。2-氨基苯基硼酸官能化的透明质酸与聚乙烯醇之间的动态交联产生水凝胶，在中性和酸性pH条件下切割或剪切后1分钟内即可恢复其机械完整性。将该水凝胶掺入互穿的海藻酸钙网络中会产生界面较硬但仍快速自粘的水凝胶，可通过在几分钟内进行简单的接触添加剂制造将其组装成空心灌注通道。这些通道可承受液体灌注，同时保持其尺寸并支持内皮细胞的生长和增殖，

更新日期：2017-12-04

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