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Cellular Biosensors with Engineered Genetic Circuits
ACS Sensors ( IF 8.2 ) Pub Date : 2017-12-07 00:00:00 , DOI: 10.1021/acssensors.7b00728 Behide Saltepe 1 , Ebru Şahin Kehribar 1 , Side Selin Su Yirmibeşoğlu 1 , Urartu Özgür Şafak Şeker 1
ACS Sensors ( IF 8.2 ) Pub Date : 2017-12-07 00:00:00 , DOI: 10.1021/acssensors.7b00728 Behide Saltepe 1 , Ebru Şahin Kehribar 1 , Side Selin Su Yirmibeşoğlu 1 , Urartu Özgür Şafak Şeker 1
Affiliation
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An increasing interest in building novel biological devices with designed cellular functionalities has triggered the search of innovative tools for biocomputation. Utilizing the tools of synthetic biology, numerous genetic circuits have been implemented such as engineered logic operation in analog and digital circuits. Whole cell biosensors are widely used biological devices that employ several biocomputation tools to program cells for desired functions. Up to the present date, a wide range of whole-cell biosensors have been designed and implemented for disease theranostics, biomedical applications, and environmental monitoring. In this review, we investigated the recent developments in biocomputation tools such as analog, digital, and mix circuits, logic gates, switches, and state machines. Additionally, we stated the novel applications of biological devices with computing functionalities for diagnosis and therapy of various diseases such as infections, cancer, or metabolic diseases, as well as the detection of environmental pollutants such as heavy metals or organic toxic compounds. Current whole-cell biosensors are innovative alternatives to classical biosensors; however, there is still a need to advance decision making capabilities by developing novel biocomputing devices.
中文翻译：
具有工程遗传电路的细胞生物传感器
对构建具有设计的细胞功能的新型生物装置的兴趣日益浓厚，引发了对用于生物计算的创新工具的探索。利用合成生物学的工具，已经实现了许多遗传电路，例如模拟和数字电路中的工程逻辑运算。全细胞生物传感器是广泛使用的生物设备，其采用几种生物计算工具来对细胞进行编程以实现所需功能。迄今为止，已经设计并实现了多种全细胞生物传感器，用于疾病治疗学，生物医学应用和环境监测。在这篇综述中，我们研究了生物计算工具的最新发展，例如模拟，数字和混合电路，逻辑门，开关和状态机。此外，我们介绍了具有计算功能的生物设备在诊断和治疗各种疾病（如感染，癌症或代谢性疾病）以及检测环境污染物（如重金属或有机有毒化合物）方面的新应用。当前的全细胞生物传感器是经典生物传感器的创新替代品。然而，仍然需要通过开发新颖的生物计算设备来提高决策能力。
更新日期：2017-12-07
中文翻译：
具有工程遗传电路的细胞生物传感器
对构建具有设计的细胞功能的新型生物装置的兴趣日益浓厚，引发了对用于生物计算的创新工具的探索。利用合成生物学的工具，已经实现了许多遗传电路，例如模拟和数字电路中的工程逻辑运算。全细胞生物传感器是广泛使用的生物设备，其采用几种生物计算工具来对细胞进行编程以实现所需功能。迄今为止，已经设计并实现了多种全细胞生物传感器，用于疾病治疗学，生物医学应用和环境监测。在这篇综述中，我们研究了生物计算工具的最新发展，例如模拟，数字和混合电路，逻辑门，开关和状态机。此外，我们介绍了具有计算功能的生物设备在诊断和治疗各种疾病（如感染，癌症或代谢性疾病）以及检测环境污染物（如重金属或有机有毒化合物）方面的新应用。当前的全细胞生物传感器是经典生物传感器的创新替代品。然而，仍然需要通过开发新颖的生物计算设备来提高决策能力。
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