An efficient one-pot synthesis of quinazolin-4(3H)-ones, benzoimidazo[2,1-b]quinazolin-12(6H)-ones and imidazo[2,1-b]quinazolin-5(1H)-ones via a palladium-catalyzed domino process has been developed. The Pd-catalyzed reactions of 2-azidobenzamides 1 with isocyanides 2 produced quinazolin-4(3H)-ones 4 at room temperature by a domino Pd-catalyzed cross-coupling/carbodiimide-mediated cyclization. However, as 2-azido-N-(2-bromophenyl)benzamides 1 were used under heating condition in the presence of Cs₂CO₃, the benzoimidazo[2,1-b]quinazolin-12(6H)-ones 5 were directly obtained by twice Pd-catalyzed domino cyclization. A domino reogioselective 5-exo-dig intramolecular cyclization reaction of alkynyl-containing azides 6 with isocyanides 2 generated imidazo[2,1-b]quinazolin-5(1H)-ones 9 in 74–93% yields in the presence of catalyst Pd(PPh₃)₄ and K₂CO₃.

高效一锅合成喹唑啉-4（3 H）-one，苯并咪唑[2,1 - b ]喹唑啉-12（6 H）-one和咪唑并[2,1 - b ] quinazolin-5（1 H）已经开发了通过钯催化的多米诺骨牌生产的一种。 在室温下，通过多米诺骨牌Pd催化的交叉偶联/碳二亚胺介导的环化作用，Pd催化2-叠氮苯甲酰胺1与异氰酸酯2生成了quinazolin-4（3 H）-ones 4。然而，作为2-叠氮基-N-（2-溴苯基）苯甲酰胺1在加热条件下在Cs ₂ CO ₃存在下使用。，通过两次Pd催化的多米诺环化反应直接获得苯并咪唑并[2,1 - b ]喹唑啉-12（6 H）-ones 5。多米诺reogioselective 5 -外掏含炔基叠氮化物的分子内环化反应6与异氰化物2生成的咪唑并[2,1- b ]喹唑啉-5（1 ħ） -酮9中74-93％的产率在催化剂存在下Pd（PPh ₃）₄和K ₂ CO ₃。