A rapid and sensitive method for the simultaneous determination of bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) in tea using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated. Sample preparation was based on a modified QuEChERS procedure through extraction of the target analytes using acetonitrile with 0.7% acetic acid followed by a dispersive solid phase extraction (d-SPE) clean up procedure using C₁₈, MWCNTs and SCX as the adsorbent mixture to eliminate tea co-extracts. The linearity of the method with correlation coefficients (R²) higher than 0.99 was obtained. The limits of detection (LODs), and limits of quantitation (LOQs) were 8.0 and 20.0 μg kg⁻¹ for BPA and 0.4 and 1.0 μg kg⁻¹ for TBBPA, respectively. Satisfactory mean recoveries of BPA and TBBPA at three fortification levels ranged from 88% to 109% and 77% to 99%, respectively, while intra-day and inter-day precisions were below 15%. The developed method was successfully applied to determine BPA and TBPA in 136 tea samples.

中文翻译：

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改进的QuEChERS样品制备方法结合液相色谱-串联质谱法同时测定茶叶中的双酚A和四溴双酚A

建立并验证了液相色谱-串联质谱法（LC-MS / MS）同时测定茶中双酚A（BPA）和四溴双酚A（TBBPA）的快速灵敏方法。样品制备基于改良的QuEChERS程序，方法是使用乙腈与0.7％的乙酸萃取目标分析物，然后使用C ₁₈，MWCNT和SCX作为吸附剂混合物进行分散固相萃取（d-SPE）净化程序以消除茶提取物。获得了相关系数（R ²）大于0.99的方法的线性。BPA的检出限（LODs）和定量限（LOQs）分别为8.0和20.0μgkg ^-1和0.4和1.0μgkg ^-1分别用于TBBPA。在三个设防水平下，BPA和TBBPA的平均回收率令人满意，分别为88％至109％和77％至99％，而日内和日间精度低于15％。所开发的方法已成功地用于测定136个茶样品中的BPA和TBPA。